Outside of these hours and on holidays, an afterhours service is available to assist you with any urgent medical. Vabomere meropenem and vaborbactam is indicated for the treatment of patients 18 years of age and older with complicated urinary tract infections cuti including pyelonephritis caused by the following susceptible microorganisms. Highlights of prescribing information these highlights do not include all the information needed to use meropenem for injection safely and effectively. Single dose minibags can be infused over 1530 minutes.
Each 500 mg meropenem for injection in the duplex container will deliver 500 mg of meropenem and a total sodium content of 245. Comparative study of the efficacy and safety of ceftazidimeavibactam plus metronidazole versus meropenem in the treatment of complicated intraabdominal infections in hospitalized adults. Each vial contains meropenem trihydrate equivalent to 1 g meropenem, and 1 g vaborbactam. Meropenem is used to treat a wide variety of bacterial infections. Meropenem injection, powder, for solution dailymed. Dailymed meropenem meropenem injection, powder, for solution. Please also see full prescribing information for azactam. The recommended dose of meropenem for injection is 500 mg given every 8 hours for skin and skin structure infections and 1 gram given every 8 hours for intraabdominal infections. Four grams of meropenemvaborbactam consists of 2 g of meropenem and 2 g of vaborbactam, and should be administered as a prolonged infusion over three hours. Meropenem is a broadspectrum carbapenem antibiotic. Meronem iv 500mg summary of product characteristics smpc. Escherichia coli, klebsiella pneumoniae, and enterobacter cloacae species complex. It is active against grampositive and gramnegative bacteria. Meropenem for injection, usp is indicated for the treatment of bacterial meningitis caused by haemophilus influenzae, neisseria meningitidis and penicillinsusceptible isolates of streptococcus pneumoniae.
Vabomere meropenem and vaborbactam for injection, for intravenous use initial u. The recommended dose of meropenem for injection, usp i. See full prescribing information for instructions on preparation of the solution, stability in intravenous fluids and drug compatibilities. Highlights of prescribing information these highlights do not include all the information needed to use primaxinsafely and effectively. Pfizer rxpathways connects eligible patients to a range of assistance programs to help them access their pfizer prescriptions.
Merrem iv meropenem for injection is a sterile, pyrogenfree, synthetic, carbapenem antibacterial for intravenous administration. Prescribing meropenem for injection in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to the patient and risks the development of drugresistant bacteria. Meropenem for injection, usp has been found to be effective in eliminating concurrent bacteremia in association with bacterial meningitis. There are no adequate and wellcontrolled studies in pregnant women. When treating complicated skin and skin structure infections caused by p. The rates of use of ertapenem 16 patients and imipenemcilastatin 14 patients were similar to one another, but substantially lower than the rate for meropenem. Imipenem 500mg q8h meropenem 500mg q8h imipenem 1g q8h meropenem 500mg q6h imipenem 750mg q12h meropenem 500mg q8h imipenem 250mg q6h meropenem 500mg q8h see full protocol details online for pediatric and renal dosage adjustment recommendations.
Merrem iv is supplied in 20 ml and 30 ml injection vials containing sufficient meropenem to deliver 500 mg or 1 gram for intravenous administration, respectively. Meropenem and its metabolite are readily dialyzable and effectively removed by hemodialysis. Dec 11, 2019 prescribing meropenem in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drugresistant bacteria. Vabomere meropenem and vaborbactam for injection, for intravenous use. Additional comments for meropenem injection, powder, for solution pdf. The osmolality of the reconstituted solution of meropenem for injection usp and sodium chloride injection usp is approximately 356 mosmolkg for the 500 mg dose. Zosyn is a monosodium salt of piperacillin and a monosodium salt of tazobactam containing a. The web version of each document is easier to navigate. Flolan epoprostenol sodium for injection, for intravenous use. Meropenemvaborbactam is administered at 4 g iv every 8 hours for up to 14 days in patients with an estimated glomerular filtration rate egfr greater than 50 mlmin1. Monographs for commonly administered intravenous medications. Meropenem fda prescribing information, side effects and uses.
Sections or subsections omitted from the full prescribing information are not listed. Highlights of prescribing information see full prescribing. Full prescribing information 1 indications and usage to reduce the development of drugresistant bacteria and maintain the effectiveness of invanz and other antibacterial drugs, invanz should be used only to treat or prevent infections that are proven or. Diflucan tablets contain 50 mg, 100 mg, 150 mg, or 200 mg of fluconazole and the following inactive ingredients. Pharmacokinetic and pharmacodynamic data were used to support the marketing authorisation in this regard. Fluconazole is a white crystalline solid which is slightly soluble in water and saline. Azactam aztreonam injection in galaxy plastic container pl 2040 for intravenous use to reduce the development of drugresistant bacteria and maintain the effectiveness.
Carbapenem antibiotics an overview sciencedirect topics. If you are in the us and would like additional information regarding astrazeneca drugs, please contact the information center at astrazeneca at 1877893151018778931510. Highlights of prescribing information these highlights do not include all the information needed to use avycaz safely and effectively. In adults with creatinine clearance of 40 mlminute or more, the recommended dosage is 2 g2 g infused over 3 hours, every 8 hours.
Highlights of prescribing information these highlights do not include all the information needed to use merrem iv safely and effectively. Monographs for commonly administered intravenous medications in home and community care 2 p a g e meropenem administration2,4,5 can be dispensed as single doses and administered by gravity or pole pump with each nursing visit. Prescribing meropenem for injection in the absence of a proven or strongly hypoglycemia, peripheral vascular disorder, and pneumonia. Below is a complete list of astrazeneca products and associated prescribing information. Meropenem readily penetrates the cell wall of most grampositive and gramnegative bacteria to reach penicillinbindingprotein pbp targets. Use normal dose every 12 hours if egfr 2650 mlminute1. Merrem fda prescribing information, side effects and uses. The dry powder should be stored at controlled room temperature 2025c 6877f see usp. Jun 01, 2016 lucasti c, popescu i, ramesh mk, lipka j, sable c. Please also see full prescribing information for azactam aztreonam for injection, usp on page 6. For information regarding use in pediatric patients see indications and usage 1. No accumulation of meropenem in plasma or urine was observed with regimens using 500 mg administered every 8 hours or 1 g administered every 6 hours in volunteers with normal renal function. See full prescribing information for subsequent dosage adjustment based on changes in renal function or therapeutic drug monitoring tdm. When culture and susceptibility information are available, they should be.
Therefore, this trial cannot determine whether the vaborbactam dose was adequate to protect meropenem against classa and classc betalactamases. Merrem iv meropenem for injection for intravenous use only prescribing information. Highlights of prescribing information these highlights do not include all the information needed to use vabomere safely and effectively. Primaxin imipenem and cilastatin for injection, for intravenous use initial u.
Merrem iv meropenem for injection prescribing information. When there are changes to the label, the pdf version will show the updates sooner than the web version. Merrem iv meropenem for injection, for intravenous use initial u. Monday to friday, 8 am to 6 pm et, excluding holidays. Meropenem is a carbapenem antibiotic structurally related to imipenem, but reportedly with less seizure proclivity.
Dailymed meropenem injection, powder, for solution. Meropenem for injection should be used during pregnancy only if the potential benefit. If there is any question about the indication for meropenem, the prescriber. The carbapenem most commonly used during the study period was meropenem, which was used in 168 patients 85%. Merrem iv meropenem for injection, for intravenous use. Invanz ertapenemfor injection for intravenous iv or intramuscular im use initial u. Prescribing meropenem for injection in the absence of a proven or strongly suspected.
For intravenous use only food and drug administration. This medication is known as a carbapenemtype antibiotic. Merrem iv meropenem is an antibiotic used to treat certain types of bacterial infections. Try out the html to pdf api safety related resources more info for this drug view all sections highlights of prescribing information these highlights do not include all the information needed to use merrem i. If you are in the us and would like additional information regarding astrazeneca drugs, please contact the information center at astrazeneca at 18778931510 18778931510. However, there is no information on the usefulness of. Merrem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis infection of the lining of the brain, and skin infections.
Meropenem for injection is useful as presumptive therapy in the indicated condition e. Antibacterial drugs other than carbapenems should be considered to treat infections in patients whose seizures are well controlled on valproic acid or divalproex sodium. Meropenem injection, meropenem usp fff enterprises. Dec 23, 2019 meropenem has been shown to penetrate well into several body fluids and tissues. Meropenem is metabolised by hydrolysis of the betalactam ring generating a microbiologically inactive metabolite.
These highlights do not include all the information needed to use meropenem for injection i. Find prescribing information for merrem iv meropenem for injection from astrazeneca. The pdf version is available to download and print. The bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Meropenem injection is used to treat skin and abdominal stomach area infections caused by bacteria and meningitis infection of the membranes that surround the brain and spinal cord in adults and children 3 months of age and older. Dos avycaz ceftazidime and avibactam for injection, for intravenous use initial u. Carbapenem utilization evaluation in a large community.
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